Sentence examples for mutation presents a from inspiring English sources

In drug discovery, a positive Ames test for bacterial mutation presents a significant hurdle to advancing a drug to clinical trials.

The mutual exclusivity of KRAS (exons 3 and 4), NRAS (exons 2, 3 and 4) and BRAF mutations was confirmed, since none of the patients with a KRAS/ NRAS mutation presented a simultaneous mutation at one of the other RAS exons tested or at BRAF.

Since its initial identification, the c.3909C>G mutation presented an unclear phenotype-genotype correlation.

The previously reported patient carrying the m.3890G>A/ MT- ND1 mutation presented an early-onset severe encephalopathy leading to death at about 3 years of age.

The patients with a filaggrin mutation presented an average vector correlation of 0.286 (SD = 0.082) while the patients without a filaggrin mutation showed an average vector correlation of 0.4 (SD = 0.08).

The large number of CD-associated gene mutations presents an opportunity to identify common mechanisms of disease as well as molecular processes that are of key importance to human cognition.

In a paper in the Journal of Medical Ethics, Smith says modern genetic studies have confirmed that the sperm of older men contains a greater number of mutations and that a minority of those mutations present a risk to the health of future children.

Nevertheless, several studies support that tumors with TP53 null mutations present a worse outcome compared with those in which TP53 harbors mutations involving overexpression.

Women carrying BRCA2 mutations present a 25%40%% risk of breast cancer development and a 10%20%% risk of an ovarian cancer development [ 108].

Actually, half of the mutations presented a level of heteroplasmy below 25%, which could be easily overlooked by automated sequence analysis.

Evaluation of the overall survival curves using the Kaplan-Meier method indicated that patients carrying BRCA2 mutations presented a lower breast cancer-specific survival in comparison with those resulted negative for BRCA2 mutations, within the first two years from diagnosis.