Sentence examples for mutation predicted to from inspiring English sources

We also examined another null mutation (ctr1-9) and a missense mutation predicted to reduce kinase activity (ctr1-4) in CTR1 (results not shown) [26], [44].

Linkage analysis studies showed that this family carries a null mutation predicted to disrupt specifically the NC11-303 ishortm (shoft) of COL18A1 common to vascular basement membranes, which is distinct from a long form splice variant expressed abundantly in the liver and heart and regulated by a different promoter [41].

To determine if mutations in aak-2 activity suppressed the enhanced anoxia phenotype in preconditioned animals, we used two aak-2 alleles (gt33 which has a 606 bp deletion in exon 3 and a presumed molecular null, and rr48, which has a point mutation predicted to disrupt the catalytic activity) [51], [59].

This contention is supported by the fact that the two FBXO7 immunoreactive bands are both undetectable in HEK 293T cells with stable FBXO7 gene KD, and in the cells from the patients with PARK15 who carry a homozygous truncating mutation predicted to affect both the FBXO7 transcripts.

Is the mutation predicted to disrupt gene expression?

PALB2 c.196C>T is a nonsense mutation predicted to produce a truncated protein (p.Gln66*).

This is a difficult problem because mutations predicted to destabilize the negative state might be accommodated by small conformational rearrangements.

Lewinsohn et al. identified five novel mutations including missense mutations within important functional domains, and splicing mutations predicted to result in truncated proteins from a family with MDS/AML (Lewinsohn et al., 2016).

Point mutations predicted to be favorable include Arg to His or Trp substitutions at position 2 and a Phe to Tyr substitution at position 3 of the hexapeptide.

Using the FoldX protein design algorithm, we generated eight NGF variants with different point mutations predicted to have altered binding to TrkA or p75NTR.

The combinations of mutations predicted to yield global optima for desired functions can then be selected and introduced into the enzymes.