Sentence examples for mutation positions with from inspiring English sources
Finally, we compared the intermolecular correlated mutation positions with available Arabidopsis SNP data [ 57].
We predicted coiled coils in this domain (see Methods) and compared the correlated mutation positions with these predictions.
Overall, the comparison of correlated mutation positions with structural data, interaction motifs and SNPs show the same trend: correlated mutations from interacting pairs have enrichment in signals compared to non-interacting pairs.
These results indicate that the mutation position within QRDR is linked with resistance to different classes of FQs.
The polymorphic positions were used instead of all of the mutation positions, including the positions with change that observed only once in the dataset, in the subsequent analysis.
Mutation positions are given with respect to the rat GC-D cDNA sequence (L37203), e.g. 1958del44 indicates a 44-bp deletion beginning at position 1958 1859_TAAA indicates that a stop codon has been created beginning at position 1859, and 924insTG indicates that the sequence TG has been inserted after position 924.
The red bar indicates the unique mutation position along with the mutated amino acid.
To assess the significance of the observed overlap between correlated mutation residues and predicted interaction motifs, random 'correlated mutation' pairs were generated by replacing each position in an observed correlated mutation position pair with a randomly generated sequence position.
For the interacting pairs, we found 207 non-synonymous SNPs without overlap with a correlated mutation position, and 19 with overlap with a correlated mutation position.
This procedure allowed us to generate a genome based on the vdB genome that was altered to a similar extent as vdB* strain, but with the mutation positions randomized.
Analysis of the number of ortholog pairs in which a given motif pair had such consistent overlap with correlated mutation positions indicates that this is higher for the interacting pairs than for the non-interacting pairs (data not shown).
