Sentence examples for mutation phenotypes observed from inspiring English sources

Although a human segmentation molecular clock has not yet been demonstrated experimentally due to the inability to examine early developmental events in human embryos, the phenotypes associated with human vertebral malformations are very similar to the mutation phenotypes observed in mice models (reviewed in [ 83]).

Three mouse models carrying heterozygous Dync1h1 mutations mimic the phenotypes observed in humans.

Notwithstanding the presence of an identical mutation, the phenotype observed in our mice was much more severe than that of Gunn rats.

Alternatively, secondary mutations in the mutant strains could explain phenotypes observed in mutants but not with RNAi.

Furthermore, we showed that the co-occurrence of Y791F with the strong RET C634Y mutation explains the aggressive MTC phenotypes observed in a large affected family that was initially reported as Y791F-only.

Because the ABCB7 substrate (or that of its yeast homolog Atm1) (Kuhnke et al., 2006) has not yet been identified, it might be time to think more broadly about the regulation of mitochondrial iron homeostasis and to integrate the phenotypes observed upon mutation of ALAS2 and ABCB7 into a single overarching model for mitochondrial iron regulation.

Most previously analysed mutations were selected because of phenotypes observed after germline transmission, and thus are unlikely to reveal mechanisms that could allow expression of the entrapment vector without disrupting expression of the occupied gene.

We speculate that the soybean ChlIa paralogous proteins interact with one another, and the contrasting phenotypes observed from mutations a few base pairs apart may demonstrate the high level of specificity required for these interactions.

Previous studies have reported WT1 mutation R394W can cause DDS or ISRNS [ 5]; therefore, we considered this mutation to be responsible for the phenotypes observed in the twins.

To date, the clinical manifestations of COL4A1 mutations in patients represent only a subset of the phenotypes observed in mice with Col4a1 mutations.

The abnormal dental phenotypes observed with MSX2 mutations have been described as AI even though there is evidence of dentine involvement.