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In the first scenario, a mutation persists in the population at low frequencies while waiting for a compensatory solution to arise de novo by mutation [ 25, 26], or as a polymorphism that may become associated via recombination [ 10].
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The mutation persisted in LR cells even after culture in the absence of lapatinib for more than 2 weeks.
Furthermore, in the absence of an autologous Nef-specific CTL response, the mutations persisted in both HLA-A2-positive and HLA-A2-negative subjects for years.
The WASP protein in patient T cells could have been transcribed primarily from a single allele if most somatic mutations persisted in cells and were only occasionally transcribed.
We compared the fitness costs associated with HLA B*8101 with those associated with B*57 and B*5801, as the HLA-association analysis suggested that for these latter alleles escape mutations persisted in advanced disease.
It is likely that these mutations persisted in vivo for a few rounds of replication in our experiments by using an internal site in this manner.
Although the dose and dose-rate effectiveness factor is used in current radiation protection guidelines, the linear concept is based on the assumption that stochastic radiation-induced oncogenic mutations persist in the target stem cells in tissues/organs.
The mutation persisted through 20,000 generations.
Without strong selection pressure against a recessive mutation that may not affect the early survival and reproduction of an individual, the mutation may persist in a population and affect individuals in a sporadic fashion.
Furthermore, ancestral haplotypes without the mutation might persist in the population [ 34, 35].
Second, it is important to note that virological studies showed that the K103N, a major NNRTI mutation, can persist in the absence of treatment [ 29].
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