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However, mutation percentages and composition have never been connected to biogeographical constraints and demographic processes related to neutral genetic variability.
Numts typically have short sequences (<200 bp) and their mutation percentages are between 5 and 25% [ 40- 43].
Assay sensitivity was therefore estimated for each mutation, by LOD using mixed mutant IDH DNA with WT genomic DNA at 5 mutation percentages i.e. 2, 5, 10, 15 and 20%.
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When corrected for mutated single samples, the mutation percentage is 39%, still slightly higher than reported.
Virologic outcome based on baseline minority variants is likely multifactorial, and is not simply based on presence or absence of a mutation or a simple mutation percentage, as some mutations and mutational loads likely can be suppressed by specific regimens, in this case a boosted PI regimen [31] [33].
Mutation percentage: 70%.
b Result variation with mutation percentage for JAYA.
Open image in new window Fig. 5 a Result variation with mutation percentage for TLBO.
The study further brings out the influence of mutation percentage on convergence.
A comparison was also performed using one-point and two-points crossover operator and the results of a sensitivity study for different mutation percentage are also showed.
This is clear from Fig. 5a, b which shows the variation of results obtained to some of the difficult problems solved by varying the mutation percentage for TLBO and JAYA, respectively.
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