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When corrected for mutated single samples, the mutation percentage is 39%, still slightly higher than reported.
Virologic outcome based on baseline minority variants is likely multifactorial, and is not simply based on presence or absence of a mutation or a simple mutation percentage, as some mutations and mutational loads likely can be suppressed by specific regimens, in this case a boosted PI regimen [31] [33].
Mutation percentage: 70%.
b Result variation with mutation percentage for JAYA.
The study further brings out the influence of mutation percentage on convergence.
Open image in new window Fig. 5 a Result variation with mutation percentage for TLBO.
Similar(42)
However, mutation percentages and composition have never been connected to biogeographical constraints and demographic processes related to neutral genetic variability.
Numts typically have short sequences (<200 bp) and their mutation percentages are between 5 and 25% [ 40- 43].
Assay sensitivity was therefore estimated for each mutation, by LOD using mixed mutant IDH DNA with WT genomic DNA at 5 mutation percentages i.e. 2, 5, 10, 15 and 20%.
The percentages of datasets that included the mutation, the percentage of mutated haplotypes as the top hit and mean length of haplotypes were calculated from the 100 simulated datasets.
In one meta-analysis of 338 transmitted point mutations, for some mutations the percentage level of mutant mtDNA tended to increase with transmission, and for others the level seemed to decrease [37].
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