Sentence examples for mutation patterns in from inspiring English sources
The interplay between transcription and mutational processes can lead to particular mutation patterns in transcribed regions of the genome.
While these pioneering studies have established the first architecture of somatic mutation patterns in pan-cancers, a detailed and deep exploration of mutational profiles within and between cancer types has not yet been performed.
The mutation patterns in LUAD in Asians might be distinct from those in LUAD in whites.
Certain carcinogens may be associated with specific mutation patterns in the p53 tumor suppressor gene, thereby contributing information about disease etiology.
The aim of this study was to evaluate gene mutation patterns in MBC patients to predict drug resistance and disease progression.
We described mutation patterns in known genetic drivers of lung adenocarcinoma and profiled genome-wide recurrently mutated loci.
To determine the sensitivity and precision of our DDiMAP approach, we used the Sanger-level IGH private sequence information from a highly mutated FL case as a biologically relevant mutation pattern in a simulation study incorporating both ongoing mutation from the initial sequence and simulated Illumina HiSeq error patterns in 100 base pair single-ended reads [ 47].
These new analyses confirmed and extended the existence of a specific mutation pattern in lung cancers of smokers, and indicate that the recent reports by Rodin and Rodin (2000) and Paschke (2000) are in error.
To validate our strategy experimentally, we analyzed the mutation pattern in a set of "positive control" samples for culture-induced variants, e.g., SCCs obtained from cells that stayed 50 days in culture before the cloning and subsequently cultured as regular SCCs.
The skewed mutation pattern in NBS1 deficient patients has not been observed in any mouse or human disease model.
Analysis of the altered mutation pattern in mice deficient in MSH2, a mismatch repair (MMR) protein, led to the proposal that SHM is a two step process.
