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Resistance mutation patterns depend on the drug and the virus subtype.
This hypothesis is clearly not valid, since mutation patterns depend on the organism considered and, within the same organism, they depend on the DNA strand and on the distance from the origin of replication in bacterial genomes [ 65], and they are thought to vary broadly within the large eukaryotic genomes.
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Applying stringent bioinformatics analyses, we narrowed down the amount of functionally significant somatic mutations in MSI to 359 and 45 in MSS cancers, thus highlighting specific mutation patterns depending on the microsatellite status.
Coefficients for the basis patterns depend algebraically on dipole orientation.
Enhancement patterns depend upon the tumor type and histology.
Firstly, we discover the mutation pattern only depending on the mutation matrix.
Mutation patterns may also depend on the genomic context such as the particular location on a chromosome and functional potential of the transcribed product [ 9, 16- 18], as well as the effectiveness of mismatch repair enzymes [ 19, 20].
Larval removal patterns depended strongly on treatment.
The mutation patterns identified through the allelism test depends on how stringent the criteria is, which is controlled by the value of α as described in the Materials and Methods section.
These results show that evolution in the absence of antibiotics can alter the fitness effects of new resistance elements, but this pattern depends on the identity of the new mutation and on the presence of other resistance mutations.
However, firm general results are difficult to obtain [ 12], as they depend upon a number of evolutionary parameters, such as details of inheritance and mutation, patterns of migration, and the nature of selection [ 12- 14].
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