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However, the influence of most mutator alleles on mutation patterns is not understood at this level.
The interplay between transcription and mutational processes can lead to particular mutation patterns in transcribed regions of the genome.
The effects of selection on the observed mutation patterns are most pronounced in relatively slowly mutating, non-CpG sites.
The mutation patterns in LUAD in Asians might be distinct from those in LUAD in whites.
We described mutation patterns in known genetic drivers of lung adenocarcinoma and profiled genome-wide recurrently mutated loci.
He demonstrated that endometrial tumors from patients with good prognoses and patients with bad prognoses have strikingly different mutation patterns.
They focused on 13 mtDNA proteins critical to heat and energy generation and discovered distinct mutation patterns for each group.
"It is possible that there are things we do not understand about mitochondrial inheritance and mutation patterns," Pääbo says.
With the development of the next-generation high throughput deep sequencing technology, scientists now are able to identify somatic mutation patterns in a certain tumor tissue, like HCC.
Her hypothesis: a microgravity environment will speed up the superbug's mutation patterns.
Differences between the organs with respect to the spontaneous mutation patterns were observed.
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