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This mutation pattern was consistent with a colonic rather than a pancreatic carcinoma [ 45].
The TP53 mutation pattern was also incompatible with a simple genetic progression model in 2 out of 7 patients.
Most of the haplotypes were singletons; this mutation pattern was more common in colonies of shallow habitats.
It was demonstrated that K101Q with H221Y as an unreported HIV-1 RT mutation pattern was associated with phenotypic resistance to the NNRTI class [ 21].
This mutation pattern was observed regardless of DNA strand direction and the sequence coverage over the site on which the methylation level was calculated.
Moreover, this highly non-random mutation pattern was found more apparent in intergenic and intronic regions than in promoter regions and CpG islands.
Similar(52)
Hence, because passenger mutations vastly outnumber driver mutations, in the absence of selection the overall SBS mutation pattern is believed to capture the composite history of the mutational processes that acted upon the tumor cells.
Such relationships were observed in the many of the sequences that showed mutant genotypes, and information of this source is important when a detected mutation pattern is being interpreted.
The mutation pattern is summarized in Figure 2B.
The mutation pattern is very likely more complex (e.g., Amos 2010).
We believe that a better way to explore the real mutation pattern is to directly capture mutations during bacterial replication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com