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A main genomic mutation parameter is estimated that describes the average number of synonymous changes genome wide, and then departures from this main effect at the gene level are explored in the framework of a log linear model.

Haplotype diversity (h), nucleotide diversity and mutation parameter, were calculated using the software DNASP (version 4.0, [ 76]).

Point estimate of the ancestral neutral mutation parameter was an order of magnitude higher than that of the current populations, but the posterior distribution was relatively flat.

To describe the infra specific molecular diversity of the regions Watterson's (θw) [ 68] and Tajima's [ 44] moment estimators of the neutral mutation parameter were calculated.

In this study, a modified self-adaptive immune genetic algorithm (MSIGA) with two memory bases, in which immune concepts are applied to determine the mutation parameters, is proposed to improve the searching ability of the algorithm and maintain population diversity.

Therefore, the plausible range of mutation parameters is not permissive for significant exponential age-dependent increases in the rates of somatic evolution (clonal expansions).

B-M mutation parameters are presented in Table 3.

Estimates for the influenza global mutation parameters are listed in Table 2.

This regime corresponds to the island coalescent model when the migration and mutation parameters are roughly on the same timescale.

Other competition indices also were tested, but no difference in estimates of mutation parameters was found among them (data not shown).

Due to the complex nonlinear functional relationship of the mutation parameters with the observed quantities in both generations, simple analytical approximations for the sampling variances of the mutation parameters are not obtainable.