This mutation overlaps with QTLs related with the number of vertebra, abdominal fat and ear morphology.
Furthermore, line widths and positions of these peaks from Fc with double F241S and F243S mutations overlapped with an N-glycan on a trypsinized Fc glycopeptide.
Considering the "selective reporting bias" as the missing data from the included studies, we assessed that the CDH1 mutations overlapped with the latest review [ 5] and with the selected original papers.
None of these polymorphisms likely cause the melanic phenotype for several reasons: (1) none of these mutations overlaps with any previously described darkening mutations, (2) all four amino acids appear in other, non-melanic individuals from other populations of P. maniculatus (Figure 4), and (3) none of the polymorphisms correlate with the melanic phenotype in this population.
Majority of HumVar mutations overlap with those in Swiss-Prot (Additional file 1: Table S2).
Some of the NCL-associated mutations overlap with PD-associated ones, suggesting a common pathway in the two types of neurological disease.
Position of mutations overlapping with known gene annotations and those resulting in amino acid changes were searched by using amino acid changes annotation module against the annotated version of Gmax_189 obtained from Phytozome FTP site [ 67].
Khuong-Quang et al. showed that the presence of ATRX mutation significantly overlapped with TP53 mutations in GBM (P = 0.01) regardless of the location within the brain and with G34V/R mutants in supratentorial GBM (P < 0.0001).
Notably, the presence of ATRX mutation significantly overlapped with TP53 mutations in GBM (p = 0.01) regardless of the location within the brain and with G34V/R mutants in supratentorial GBM (p < 0.0001), and were age-dependent as they mainly occurred in older children (p < 0.0001).
H3.3 mutations significantly overlapped with mutations in TP53 and in ATRX (α-thalassemia/mental-retardation syndrome-X-linked) [ 13, 40] and less frequently with the ATRX hetero-dimer DAXX, which encode subunits of a chromatin remodeling complex required for H3.3 incorporation at pericentric heterochromatin and telomeres [ 8, 13].
