Sentence examples for mutation over time from inspiring English sources

The worldwide spread of the disease is providing more opportunities for viral re-assortment within a host (genetic shift) and mutation over time (genetic drift).

Latency is common in tuberculosis infection and could result in considerable discrepancies in the apparent rate of mutation over time.

Clonal selection of cells harboring this mutation over time is thought to lead to refractoriness to erlotinib and gefitinib.

Another, not mutually exclusive explanation for the observed pattern would be short population persistence times, not allowing to accumulate genetic variation by gene-flow or mutation over time.

This pattern is consistent with one or a few closely related initial clonal founder individuals giving rise to occasional new genotypes by mutation over time.

When protein-coding genes are subjected to occasional mutations over long time periods, they manage to undergo substantial sequence change while maintaining their original function.

They also replicate, introducing new mutations over time that can change the data.

Tissue-specific stem cells may accumulate certain mutations over time that initiate carcinogenesis, causing them to become cancer stem cells.

This may be attributable in part to quiescent LSCs residing in the protective niches that acquire additional mutations over time.

We can therefore attribute differentiation between Group 1 and temperate japonica varieties originating in South Korea, Japan and China to mutation, observed as an accumulation of step-wise mutations over time (Balloux and Goudet [2002]).

It is likely that older twin pairs will have accumulated more somatic de novo mutations over time [45] and this will be expected to affect the degree of somatic mosaicism across tissues [49].