Sentence examples for mutation or variable from inspiring English sources

Further study is needed to identify the source of this region's variability – perhaps transposable element insertion-related activities, local enhancers of spontaneous mutation, or variable selection pressures.

Given the vast complexity of the EGFR signaling network, it is hardly surprising that genetic factors beyond EGFR mutations or variable expression patterns may modulate therapeutic responses to EGFR-targeted agents.

This is not invariably going to be the case and many "disease-causing mutations" will display reduced or variable penetrance for a variety of different reasons (reviewed by Cooper et al. 2013).

Reduced diversity is substantially more common in models with less mutation or models with less variable mutation effects.

Collective analysis of similar studies would help to truly dissect the underlying molecular mechanisms of the heterogeneous phenotypes in DBA patients with similar or variable gene mutations.

The difference between codes 5 and 9 is that variants with code 5 are expected to have a universal effect on drug response based on mutation type, whereas the broader effect of those with code 9 is either unknown or unsupported based on the type or location of the mutation, or based on the observed variable or drug-specific effects.

Having observed that rict-1 effects on lifespan are profoundly influenced by the bacterial food source, temperature, and the mode by which rict-1 function is disrupted (mutation or RNAi), we incorporated these variables into an analysis of how sgk-1 influences stress resistance and lifespan.

A binary mutation marker variable takes a value of 0 or 1 to represent the absence or presence of a mutation, respectively.

Molecular characterisation of early-onset CRC is important to clarify whether this clinical feature is caused by dominant germline mutations with variable penetrance or arising de novo, by recessive inheritance, or are merely sporadic events.

There are exceptions to the rules of classical pathogenic mtDNA mutations, which are defined as a category of human, maternally inherited disorders characterized by a homoplasmic mtDNA pathogenic mutation with variable penetration and stereotypic clinical expression.

IGVH mutation (Immunoglobulin variable region heavy chain) analysis was performed on the CLL specimens with multiplexed PCR reactions to assess clonality as previously described [ 29].