Sentence examples for mutation or truncation from inspiring English sources

The acceleration of channel deactivation by KCNE1 C-terminal point mutation or truncation also renders the channel incapable of adapting to increases in heart rate, which may contribute to some LQT5 phenotypes.

Finally, we show that either helicase mutation or truncation of the C-terminal half of Mov10, where a putative RNA-helicase domain is located, maintained most of its HIV inhibition; whereas removing the N-terminal half of Mov10 completely abolished its activity on HIV.

Met resistance is frequent in all H. pylori strains, and is often due to mutation or truncation of the RdxA.

Mutation or truncation of the dimerization motif in TRPM7 inhibits kinase activity [ 23], but how this affects ion channel activity has not been studied.

However, secreted 5'nucleotidase/apyrases lack the amino acids needed for anchor attachment [ 20, 21, 38, 52], either through mutation or truncation.

One gene is disrupted in wAu relative to wMel, by a nonsense mutation, and four genes are disrupted in wMel relative to wAu, by frameshift, nonsense mutation or truncation.

Although it remains to be clarified which of the molecular alterations of TDP43 -overexpression, pathological mutation or truncation-, is responsible for the pathological changes observed in ALS patients, it is probable that similar dendritic retraction as supported in the present study in human autopsy samples is fundamental to ALS pathogenesis.

Many researchers are not interested in HT screens nor have the resources for large screens in their departments, but want to detect miRNA targets, mutations, or truncation of regulatory elements in the 3′UTR of their gene of interest.

The expression of functional components of the network and the fact that there are no mutations or truncations in the genes encoding β-catenin or Adenomatous polyposis coli (APC), make these cells an attractive model to study normal Wnt signaling.

There are several possible sources of protein destabilization for AL proteins: 1) somatic mutations that cause the protein to sample partial unfolded states, 2) proteolytic cleavage that removes the constant domain, and 3) loss of the interaction with the HC due to mutations or truncations in LC or HC.

The presence of mutations or truncations was confirmed by mass spectrometry analyses.