Sentence examples for mutation or phosphorylation from inspiring English sources

Therefore, we anticipated that mutation or phosphorylation of Y1065 within Vt would not affect PIP2 association.

If signal changes correspond to residues near the site of mutation or phosphorylation, this would indicate that the mutation or phosphorylation likely had little effect on the global structure and dynamics of the protein.

However, a small subset of NH peaks show changes in chemical shift and/or line width upon mutation or phosphorylation of Y1065.

In conjunction with our CD and Tm results, these data indicate that mutation or phosphorylation of Y1065 does not significantly alter the helix bundle fold.

To evaluate if mutation or phosphorylation at Y1065 alters the stability of Vt, we performed fast quantitative cysteine reactivity (fQCR), a technique that uses a thiol-reactive fluorescent indicator that covalently modifies cysteines as they become exposed when the protein unfolds over a thermal gradient.

In the GluR4 study, mimicking phosphorylation (S842D mutation) or preventing phosphorylation (S842A mutation) of the S842 site enhanced synaptic expression of the receptor [22].

Taken together, the mutation Y105E, or phosphorylation of residue Y105, inhibits FBP association and prevents the FBP-induced R-state formation of PKM2.

These findings highlight an attractive scenario in which Tyr682 may be a crucial actor in APP/Aβ signaling such that a disruption of APP binding to adaptors, mediated by a Tyr682 mutation or altered phosphorylation status, may lead to neuronal defects and decline.

In tumor cells the pRB-E2F interaction may be distured by different ways, including mutations or inappropriate phosphorylation of pRb due to Cdk4 orCdkinasesses overexpression or loss of the p16ink4a inhibitor [ 1].

Similarly, it has been reported that Nlp mutants harbouring KEN-box and D-box mutations or respective phosphorylation-sites mutations of Plk1, Cdc2 or Aurora B kinases show resistance to proteolysis (Casenghi et al, 2003; Wang and Zhan, 2007; Yan et al, 2010; Zhao et al, 2010).

AAV2 and AAV8 are the closest parental vectors of AAV-DJ and it has been reported that mutations on the 137/251/503 ubiquitination or phosphorylation sites of the AAV2 or AAV8 capsid lead to dramatic enhancement of gene delivery.