Sentence examples for mutation or multiple from inspiring English sources

In an spt10 Δ background, no single suppressor mutation or multiple suppressor combination restores mRNA levels for any histone gene.

However, it can be the result of a single mutation or multiple mutations on different chromosomes in human.

The mutations can accumulate sequentially without ever passing through a low-fitness intermediate (as in Maynard Smith's analogy), an initial deleterious mutation can be compensated by a subsequent mutation, or multiple mutations can occur simultaneously.

Because the 2214 X chromosome failed to complement vs but not if, it was designated vs. Further complementation tests confirm that the 2214 X chromosome contains a mutation (or multiple mutations) in the approximate genomic position of the vesiculated gene.

Although a mutation or multiple successive mutations in a single cell as the initial step cannot be ruled out, there are many experiments, such as the aforementioned foreign-body induced cancers, that are inconsistent with a mutation causing the initiation of cancer.

A family history of breast cancer is a significant risk factor for the development of the disease; at least 10 to 15% of all breast cancer cases may be due to inheritance of a single gene mutation or multiple genetic variants [ 2- 4].

(A) The phosphorylated threonine and serine residues shown in Fig. 1D were mutated to alanine, and Atg31 mutants with single mutations or multiple mutations in various combinations, as well as Atg31 deletion mutants, were assessed for autophagy activity under nitrogen starvation conditions.

We explored the impact of co-mutation (double or multiple mutation), compared with a single mutation, of the EGFR gene on response to TKIs in a series of patients with metastatic NSCLC.

To create single mutations or multiple allelic variants, QuickChange XL site-directed mutagenesis kit (Stratagene) was used (The primers and cloning scheme for the different constructs is described in table S3).

Several lines exhibited multiple step changes from the progenitor sequence, although it is unclear whether these are multi-step mutations or multiple single step mutations.

Patients with other different mutations or multiple types of mutations will be assigned to receive sunitinib since almost all these tumours have elevated levels of VEGF/ VEGFR expression.