108, 109 Inhibiting the function of BIM and PUMA or inducing MCL-1 are, as discussed previously, also the consequence of promoter methylation, MYC mutation or increased mTORC activity, all described in BL.
EGFR mutations or increased EGFR gene copy number assessed by fluorescence in situ hybridization (FISH) identify NSCLC with the highest chance to respond to the therapy.
It is not known whether genetic exchange occurs in populations of T. vaginalis; however, genetic exchange could mediate the proliferation of drug-resistant mutations or increased virulence in populations of the parasite.
Recent studies have addressed the relationship between response and either sequence mutations or increased copy number of specific receptor tyrosine kinases.
Patients with EGFR gene mutations or increased gene copy numbers are more sensitive to anti-EGFR therapies, including tyrosine kinase inhibitors and monoclonal antibodies.
A direct causal role for αS in neurodegeneration is supported by missense mutations or increased copy number of the αS gene (SNCA) in some patients with Parkinson's disease and the related disorder dementia with Lewy bodies [ 4- 11].
The expected pattern of TP53 alterations was seen with respect to intrinsic classification: mutations or increased protein expression were seen in 70%, 57%, 42% and 15% of HER2-enriched, basal- like, luminal B and luminal A tumors, respectively.
The presence of a TP53 alteration (either a mutation or an increase in protein detection) was correlated with the G2I (Table 5) (p =0.0003).
Human neurological disorders may also be induced by 'dynamic' mutations (reduction or increase in the pattern copy number of a tandem repeat) in both coding regions and noncoding regions; such mutations are not limited to occurring with triplet microsatellites (9 11).
To investigate whether there is an association between recombination and increased basal mutation rates or increased degrees of selection favoring the survival of mutations, we compared the mutation dynamics of the MSV-MatA and MSV-VW field isolates of Maize streak virus (MSV; Mastrevirus), with both a laboratory constructed MSV recombinant, and MSV recombinants closely resembling MSV-MatA.
Other possibilities are that the associated haplotype causes the JAK2 gene to be more susceptible to mutation or allows increased survival of JAK2V617F alleles.
