Sentence examples for mutation or inactivation from inspiring English sources

It is possible that TP53 is inactivated through INK4A/ARF mutation or inactivation in our tumor model, similar to Myc-induced lymphoid tumors in mice [ 79, 80].

Hence, small number of S. pyogenes CRISPR spacers may result from a mutation or inactivation of Cas1.

In human cancers, p53 mutation or inactivation can be an early or late event, though it is unlikely to be an initiating event in most cancers and usually occurs during cancer evolution or progression [1], [5], [6].

Mutation or inactivation of p53 is known to be present in approximately 50% of human cancers.

About 70% of clear cell RCC features mutation or inactivation of the VHL tumor suppressor gene.

Mutation or inactivation of ras and p53 oncogenes are the most common genetic events identified for almost all human cancers, including head and neck squamous cell carcinomas.

Furthermore, other exon mutations or inactivation mechanisms such as deletion or methylation could have inactivated p16 (Lu et al. 2004; Zhao et al. 2003).

Loss of p53 suppressor function, through mutations or inactivation of the p53 pathway, occurs in most human cancers.

Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson's disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum (STR) regions.

Overall, 21 of the 22 tumours had p53 alterations either by mutation, deletion or inactivation by mdm2 or HPV.

The aim of the study was to determine the incidence of p53 alterations by mutation, deletion or inactivation by mdm2 or human papillomavirus (HPV) infection in recurrent squamous cell cancer of the head and neck (SCCHN) refractory to radiotherapy.