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No allelism was found in NRAMP1 corresponding to the murine mutation, or in the two coding regions.
No evidence of BRCA LOH was observed in the cells from PO49, which contained a TP53 mutation, or in the seven additional specimens in which p53 overexpression, but not mutation, was observed.
Remaining frameshifts and point mutations are considered to be authentic and were annotated as "authentic frameshift" or "authentic point mutation", or, in the case of multiple lesions within a single ORF, "degenerate".
In contrast, no such effects were observed in BCR-ABL-negative Ba/F3, Ba/F3 harboring the highly IM-resistant T315I mutation, or in HL60 cells (Figure 2A F).
Many mutations identified as causing hypertrophic cardiomyopathy have been investigated with recombinant proteins incorporating the mutation or in transgenic mouse models.
A recent paper showed that the p14/ARF protein was frequently down regulated in lung cancers with EGFR mutation or in tumors with ERBB2 mutations.
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Among the many alterations that have been detected, L858R missense mutation or in-frame deletion at exon 19 are the most dominant, conferring hyper tyrosine kinase activity and stabilization of protein expression.
No secondary resistant mutations such as T790M mutation or insertions in exon 20 were found in those patients.
The condition can be caused by drug use, genetic mutations, or in utero infections.
Cooperation could be acquired through mutation or assigned in advance.
Most mastocytosis patients have a point mutation or mutations in c-kit, the gene encoding the SCF receptor Kit.
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