Sentence examples for mutation or alternative from inspiring English sources

Though the mechanisms of escape from anti-PD-1/PD-L1 remostlyostly unknown, one possible concern is that the administration of anti-PD-L1 MAbs would increase the possibility of MAb driven off-target escape derived from PD-L1 mutation or alternative splicing driven isotype switch.

Mechanisms by which cellular deregulation of MET occurs include overexpression, genomic amplification, mutation, or alternative splicing.

Tumor cells must then acquire a metastatic phenotype, generally through mutation or alternative activation of proinvasive molecular pathways [7].

Collectively, these observations demonstrate that a PTC, introduced either by point mutation or alternative splicing, is able to potentiate miRNA-mediated rapid deadenylation of the mRNA by unmasking ORF miREs downstream of it.

The peptide variants resulted from DNA mutation or mRNA alternative splicing are sometimes also considered as novel peptides.

Here, the novel peptides are those from the previously unannotated region on a genome, excluding the peptide variants resulting from DNA mutation or mRNA alternative splicing.

These changes result in either an exonic missense mutation or interference with alternative splicing, disrupting the ratio of tau isoform expression (Hutton et al., 1998).

Here it could be inferred that the conservation of intron insertion with phase 1 but not phase 0 or 2, which has a redundancy at the 5' or 3' side of introns, was probably the most plausible mechanism to result in an all-or-none or alternative mutation, that is, conservation or fetal.

Additional examinations, regarding any mutations of the genes or alternative splicing of mRNA have not been performed.

Several studies show that there are physiopathological crossovers between diseases associated with PP-TMA, for example low ADAMTS13 activity in HELLP or mutation in alternative complement pathway which induced HELLP.

Of note, due to the lack of high-quality genomic DNA from these clinical samples we could not discriminate in these samples whether METΔ7 8 resulted from a mutation or from exon skipping or alternative splicing, such as suggested for MET variants lacking exon 10 or 14 [ 37].