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Many areas of food mycology could be affected detrimentally by mutation of wild type fungi.
The mutant 'Hong Anliu' sweet orange (MT) is a spontaneous bud mutation of wild type 'Anliu' sweet orange (WT); and they are with isogenic background as revealed from our previous physiological traits and molecular marker evaluations [ 11].
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The mutation showed to be truly somatic, as the sequence of AKT1 derived from benign prostatic tissue of patients carrying the mutation was of wild type (data not shown).
Mutation context of wild type versions of AID and APOBEC3G are shown in Figure 3 figure supplement 1. Analysis of additional yeast transformants and breast cancers is shown in Figure 3 figure supplements 2 4.
Phospho-mimicking mutations of wild-type eNOS at S635 and S1179 synergistically activated the enzyme.
In contrast, mutations of wild-type p16 and PTEN increase resistance of U87 cells to statins (Supplementary Figure S6).
The disorder is characterized by focal cyst formation that involves somatic mutation of the wild type allele in a large fraction of cysts.
Sporadic renal tumours require spontaneous mutation of two wild type VHL alleles [ 30].
We did not find reduced expression or somatic mutation of the wild allele in only two LTs.
It is not known whether hermaphrodism evolved through sexual recombination, as a mutation of the wild form that was then introgressed into cultivated varieties, or as a mutation that originated in cultivated forms.
To determine the extent to which exposure to Mn2+ increases the accumulations of mutations and to quantify the increase in the mutation rate of wild-type yeast cells, we utilized the CAN1 forward mutation assay [ 33], as described in Section 2. As shown in Figure 4, the mutation rate increased 12-fold (from 1.9 × 10−7 to 23.1 × 10−7) when wild-type cells were treated with 1.5 mM Mn2+.
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