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The loss of function, dysregulation, and mutation of various RBPs has been implicated in a host of human diseases.
Since we used the same fossil-based calibration points as previous researchers and identical settings for the analysis, this result is most likely attributable to the difficulties inherent in modeling the inherently heterogeneous patterns of mutation of various mtDNA protein-coding genes.
We have recently developed a real-time PCR-based approach to rapidly screen for mutation of various genes including KRAS by using in-house developed Taqman probes that specifically recognize wild type and mutant alleles of each gene.
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Because ferns are an ideal system in which to study the inheritance patterns of various genetic traits, numerous strains of water fern, with individual genetic mutations of various sorts, have been bred and are maintained in culture collections, and detailed instructions on creating new mutant lines have been developed.
Disease-related mutations of various Nav channels are systematically mapped onto this Nav1.7 structural model.
We also investigated the effect of S1-resistance on Notch1 activation by a panel of T-ALL associated NRR mutations of various classes (Figure 8).
We identified over forty mutations of various types in QM9123 and/or QM9414.
Mutations of various pathways including MAPK, PI3K and Wnt have been described as potential drivers of this malignancy [ 5, 6].
CC was first described by analysing Minute (M) mutations in Drosophila [ 11], a group of dominant, homozygous-lethal mutations of various ribosomal genes.
Efforts to characterize the most prevalent mutations of various cancers by The Cancer Genome Atlas (TCGA) Research Network have revealed recurrent mutations in specific pathways.
As next-generation sequencing data of different human cancers continue to accumulate, abounding tumor-associated mutations of various types are being discovered and further analyzed.
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