Sentence examples for mutation of unknown from inspiring English sources

In patient 11872.p1, another risk mutation of unknown functional relevance (splice site mutation in KATNAL2) was reported (24).

In studying the effects of BRCA1 R1699Q, a mutation of unknown clinical significance, Chang and colleagues discovered a novel mechanism for BRCA1 as a tumor suppressor gene [ 9].

Approximately 50% of affected people inherit the disorder; in others the disorder is caused by a spontaneous genetic mutation of unknown cause.

The bioinformatic analyses using PolyPhen-2, SIFT and PROVEAN tools predicted that this variant is not pathogenic, and therefore we classified this missense mutation as a new mutation of unknown significance.

The eam5 locus was described as a mutation of unknown origin isolated from an ICARDA/CIMMYT selection CMB85-533 (Higuerilla*2/Gobernadora) and mapped onto chromosome 5H (Jain 1961; Franckowiak 2002).

Although short coding exons of both BRCA1 and BRCA2 were analyzed by either direct sequencing or heteroduplex analysis, only the BRCA1 c.181T>G (c.300T>G; p.C61G) missense mutation and BRCA2 c.3075G>T p.K1025NN) missense alteration (present in conjunction with the K1026X nonsense mutation) of unknown clinical significance were observed.

The German study correlated SIDS cases with a specific haplotype within the displacement loop [ 90], whereas the Norwegian study identified four mutations of unknown significance, while no controls were mutated [ 91].

I would think that the latter is safer than the irradiated former, given that irradiating seeds can cause multiple mutations of unknown effect.

Thirteen missense mutations of unknown significance were also identified.

Mis-sense mutations of unknown significance were found in three patients.

Cancer genomes contain numerous genes with low-frequency mutations of unknown functional significance.