Sentence examples for mutation of tumor from inspiring English sources

Constitutive activation of Wnt signaling caused by the mutation of tumor suppressor APC leads to breast cancer stem cell (BCSC) expansion.

Multiple cellular and molecular alterations such as amplification or overexpression of oncogenes, hypermethylation or mutation of tumor suppressor genes, activation of cancer stem cells, and infiltration of immune cells, contribute to the malignant transformation of HCC.

Several common genetic alterations have been detected in squamous cell tumors, including upregulation of oncogenes and mutation of tumor suppressor genes [1], [2].

We also identified an R273H mutation of tumor suppressor p53 after chronic exposure to NNK.

Consequently, activation of cellular oncogenes and mutation of tumor suppressor genes might play a less substantial role in the initiation of KS relative to other sarcomas.

In the past, it was generally thought that genetic mutation was a key event of tumor pathogenesis, especially somatic mutation of tumor suppressor genes.

Cancer type Mutation/tumor Respiratory/lung cancer 200 300 Skin/melanoma 100 200 Esophageal/colon cancer 50 100 Pancreatic, ovarian 30 60 Breast 20 70 Hematopoietic cancer 1 10 (CML/AML/ALL/CLL) rhabdo/myo/sarcoma 1 3 Mutations of tumor cells were based on means of mutation in single patients (CML/AML/ALL/CLL) Soft tissue/rhadomyoscarcoma.

We found, as expected, that most inactivating mutations of tumor suppressor genes were frequently accompanied by loss of the wild type allele.

Tumor angiogenesis can be triggered by extracellular signals such as growth factors, by genetic alterations such as activation of oncogenes, and by mutations of tumor suppressor genes such as PTEN and p53 [16], [16].

The second generation of GEM comprises conventional knockouts with targeted mutations of tumor susceptibility genes.

These results indicated that AR‐positive TN breast cancer possessed PIK3CA kinase mutations of tumor gDNA.