Sentence examples for mutation of target from inspiring English sources

These include mutation of target genes, amplification of target and mutated genes, differences in repair capacity, altered drug transport and differences in nucleoside and nucleobase salvage pathways (Fox et al, 1991).

The cascade recognition strategy contains a toehold mediated strand displacement and a double-toehold mediated double strand displacement reaction, thus enable the high ability to discern point mutation of target.

This enables the mutation of target genes in normal hPSCs: kidney organoids differentiated from these cells can then be used to model kidney disease caused by these genetic modifications, and the parental hPSC line is an ideal control, as all other genes will be the same.

Therefore, while mutation of target lysine residues reduces the specific auto-ubiquitination of TRIM5αrh in vitro, it does not prevent formation of Ub chains.

Known factors that lead to drug resistance include (i) induction of drug transporters, (ii) activation of DNA repair, (iii) changes in drug metabolism, (iv) gene amplification or mutation of target proteins and (v) changes in survival/apoptotic pathways.

Furthermore, mutation of target lysine residues sometimes can lead to the modification of lysine residues that do not normally participate as ubiquitination sites (Hou et al., 1994; Marotti et al., 2002).

Mechanisms involved include modification of the drugs to less toxic derivatives or avoidance of their action by exclusion, target modification, and mutation of target-associated genes.

Detailed transcription start site mapping and experimental mutation of targeting peptides would allow us to distinguish among these possibilities in diatoms.

Multiple experimental approaches have been applied to generate nearly all possible mutations of target enzymes, allowing the identification of desirable variants with improved properties to meet the practical needs.

In addition, mutations of target sequences are always a possibility that may reduce the efficiency of primer-binding sites resulting in inefficient amplification and detection failure.

Various mechanisms of resistance to antibiotics are well known, such as antibiotic removal by antibiotic pumps, modification of their structure by enzymes or mutations of target sites [ 25, 26].