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It is tempting to speculate that MAPK activation in uveal melanoma may arise via crosstalk with the PI3K/PTEN/AKT pathway, possibly as a consequence of mutation of some of its components (other than PTEN, which is not mutated in this tumour type).
I seem to be a changeling or a throwback or a mutation of some sort in a highly respectable old New England family.
It will be of interest to investigate the effect of mutation of some of these phosphorylation sites on resection speed as well as on NHEJ activity.
Abnormal expression and/or mutation of some oncogenes and cancer suppressor genes occurs during each step of carcinogenesis [8].
Mutation of some genes involved in the function of T3SS reduced the virulence of A. hydrophila SSU and A. veronii in mice and that of A. hydrophila AH-1 in blue gourami fishes [13], [36], [37].
Our results show that mutation of some of highly conserved residues lead to a loss of biological activity and that these defects are due to impaired DNA binding affinity or specific target DNA cleavage, indicating that these conserved residues located both in the N-terminus and C-terminus region of phiC31 integrase are essential in DNA recombination.
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The megalocytic and dysmorphic neurons may result from somatic mutations of some, but not all, neuronal precursors in the periventricular region.
A main open question related to character-based tree reconstruction is designing generalizations of the Perfect Phylogeny approach that couple efficient algorithmic solutions to the capability of explaining the input binary data, by allowing back mutations of some characters.
On the other hand, knowing that Mutation Test has a high application cost, another possibility is to try to identify mutations of some specific mutation operators, which an automatic static analyzer is not adequate to detect.
The genetic mutations of some of the diseases have been identified and are being studied as well.
We also tested the effects of alanine substitution mutations of some conserved residues (e.g., Lys51, Tyr119, and Glu122) in TEM8.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com