Sentence examples for mutation of only from inspiring English sources

Interestingly, while mutating 32 phosphorylation sites did not alter Rap1 function, mutation of only two highly conserved residues (D-337 and D-338) disrupted its ability to bind to the Bqt1-2 causing, causing pronounced defects in telomere clustering and chromosome segregation.

In a first approach a trisaccharide bearing a β-d-N-acetylglucosaminyl residue was docked at the +1 subsite of H. insolens Cel7B, indicating that the mutation of only one residue, His209, could lead to the expected wider acceptor specificity.

Site-directed mutagenesis is a powerful tool to explore the structure function relationship of proteins, but most traditional methods rely on the mutation of only one site at a time and efficiencies drop drastically when more than three sites are targeted simultaneously.

Surprisingly, Rb1ΔL/+ MECs have a similar defect in TGF-β growth control indicating that mutation of only one copy of Rb1 is sufficient to abrogate its arrest mechanism.

In agreement with this, while mutation of only two lysine residues in this sequence (m14 15) resulted in increased nucleoplasmic and reduced nucleolar fluorescence relative to wild-type L22, mutation of all four lysine residues (m13 16) resulted in retention of L22 in the cytoplasm (Fig. 6A).

Mutation of the p16 CR site predicted to be targeted by miR-24 (mCR) or both the CR and 3'UTR sites (mCR+m3') effectively abrogated this induction in EGFP expression, while mutation of only the 3'UTR (m3') had a partial effect (∼3-fold induction), as shown in Fig. 8.

Of note, the exon 4, from which the most frequently mutated alleles in CDA II patients (E109K) stem, showed a relative richness of mutations of only 1.9%.

Human genome consists of around 21,000 genes [ 31], while most diseases are associated by mutations of only a few genes.

Yoshida et al. previously reported a true-positive rate of candidate mutations of only 53.9% using WES data from patients with myelodysplastic syndrome (MDS) [ 25], indicating that the haploid nature of our mutant cells is advantageous for the accurate determination of mutations compared with diploid cells such as those of MDS patients.

Of the 84 patients, there were only 24 patients with EGFR mutations for an EGFR mutation rate of only 28.6%%.

Hu et al. reported a mutation incidence of only 3.03% in 33 ESCCs [ 28] and no mutations were detected in the hot spot exon 5 (Table  3).