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UniProt DB describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.
The change in expression of one or more starch biosynthesis enzymes could result in the observed properties of o2 starch, although altering the expression or mutation of one starch biosynthetic enzyme can have complex effects on multiple enzyme activities.
The simplest explanation for the attenuated phenotype for CDC684 would be the mutation of one or more of the virulence factors encoded on the pXO1 or pXO2 plasmids that altered expression or function.
In E. amylovora, mutation of one of the exopolysaccharide genes, wceB, impaired pathogen EPS biosynthesis and reduced virulence on apple [ 48].
Furthermore, mutation of one of the key hydrophobic residues of KR-12 to Ala significantly reduced the antibacterial activity of the peptide mutants.
Maquettes have been designed following the [FeS]-cluster-binding motif of dimethyl sulfoxide reductase subunit B (DmsB) from Escherichia coli that carries a [Fe4S4]-cluster, but incorporates a [Fe3S4]-cluster instead upon mutation of one of the coordinating cysteines.
Mutation of one or more of these residues generates a "pocket" in the ATP binding site that allows the mutant kinase, but not other cellular kinases, to utilize analogs of ATP with bulky substituents synthesized onto the N-6 position.
Mutation of one gene causes lethality.
Like most of cancers, bladder cancer begins with the mutation of one single cell [16, 17].
The mutation of one allele is a partial knockout because this cell line has multiple CFTR alleles.
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With fully suppressive therapy, the populations of both WT and mutant virus drop toward extinction, as back-mutation of one quasispecies can no longer contribute to sustaining the others.
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