Sentence examples for mutation of mitochondrial from inspiring English sources

The mitochondrial theory of aging was based on the idea that there exists within mitochondria a vicious oxidation cycle, in which the mutation of mitochondrial DNA impairs the function of proteins in the organelle's respiration machinery, thereby enhancing the production of DNA-damaging oxygen radicals.

The mutation of mitochondrial respiration components, such as clk-1, the enzyme in ubiquinone synthesis, was shown to reduce the oxygen consumption.

For example ROS lead to an increased expression of matrix-metalloproteinases resulting in degradation of the dermal connective tissue [11] and induce common deletion mutation of mitochondrial DNA, a molecular hallmark of photoaging [12].

Detection of the 3243A > G mutation of mitochondrial DNA confirmed the diagnosis of MELAS syndrome in the patient, his sister, his mother and one of the mother's sisters.

We recently reported that oxidative stress elicited by chronic inflammation increases the mutation of mitochondrial DNA (mtDNA) and possibly correlates with precancerous status.

We report the case of a patient with MELAS syndrome and the "classic" 3243A > G mutation of mitochondrial DNA, who developed kidney cancer and severe and rapid kidney functional impairment after unilateral nephrectomy.

Other computer animations offer insights into how scientists decode the hereditary information, how it is transmitted through generations, and how mutations of mitochondrial DNA, the traits inherited through the mother's lineage, reveal relationships through time and migrations.

As mitochondria are derived through the oocyte (only one case of paternal inheritance of mitochondria DNA has been identified- Schwartz & Vissing 2002), disease caused by mutations of mitochondrial DNA display a maternal inheritance pattern.

Mutations of mitochondrial DNA (mtDNA) can cause diseases such as MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) and Leber's hereditary optic neuropathy.

Mutations of mitochondrial DNA are linked to many human diseases.

It was reported that cells accumulate somatic mutations of mitochondrial DNA as part of normal ageing.