Sentence examples for mutation of many from inspiring English sources

The Cre-loxP system has been used to enable tissue specific activation, inactivation and mutation of many genes in vivo and has thereby greatly facilitated the genetic dissection of several cellular and developmental processes.

Indeed, systematic mutagenesis of identified phosphorylation sites showed that mutation of many phosphorylation sites affects FRQ stability.

Aberrant expression or mutation of many of the lineage-specific TFs involved in B lymphocyte development have been linked to the outcome of hematopoietic malignancies.

This is to be expected as rates of mutation of many nuclear genes (especially protein coding) are generally not as high as that typically found in most mitochondrial genes.

Neoplastic cells frequently hijack their normal physiological function to survive, proliferate, evade the immune system, induce angiogenesis, and promote invasion and metastasis, and the aberrant expression or mutation of many GPCRs have been linked to various cancers.

Transcription termination occurs up to several hundred bases downstream of the 3′ end processing site even though both processes are intimately linked and mutation of many 3′ end processing factors results in transcription termination defects [48,76,93,98,102 105].

In a new paper, Harvard researchers show that changes in coat color in mice are the result not of a single mutation, but of many mutations, all in a single gene.

The causative mutations of many patterns remain unknown.

Human homolog mutations of many genes with photoreceptor-associated expression have been shown to be associated with retinal diseases including RP [27].

Over-expression as well as both activating and inactivating mutations of many KMTs correlate with cancer [16].

Indeed, the role of this pathway in tumorigenesis has been extensively investigated and altered expression or mutations of many components of this pathway have been implicated in human cancer (Vivanco and Sawyers, 2002).