Sentence examples for mutation of key from inspiring English sources

Mutation of key coiled-coil residues destroys looping and causes a loss of Ter condensation in vivo.

Notably, mutation of key residues inside the mCAR ligand-binding pocket entirely eliminated the stimulatory effect of TCPOBOP, as well as the inhibitory effect of androstanes, without affecting the constitutive activity of CAR (Tzameli et al., 2000).

In gut, the mutation of key tumor suppressor molecules in the Wnt signaling pathway leads to amplification of stem/progenitor compartments, followed by the appearance of differentiated adenomas and tumors [6], [7], [8].

This effect does not reflect a loss of SH3 domain function since mutation of key WW residues in the SH3 domain that are needed for SH3 domain binding did not interfere with binding between SKAP-55 and RasGRP1 (data not shown).

The allosteric binding of SGC707 to PRMT3 was confirmed by X-ray crystallography and mutation of key residues in PRMT3.

Importantly, mutation of key residues in the Syx RBD, correlating with the Raf1 side chains responsible for Ras-binding, abolished Syx-Rnd3 complex formation.

Here we report mutations of key catalytic residues within CDTa and their effect on CDT cytotoxicity.

The mutations of key residues significantly alter the folding by distorting the cooperative interactions, which can result in the misfolding or aggregation; nonetheless, the rational design by mutations can be beneficial to protein folding.

Mutations of key residues involved in Greek-key motiformationon in γD have been associated with more severe cataracts than those occurred at the loops, termini or surfaces of β/γ-crystallins (Vendra et al., 2013).

Single-mutation of key HyPRE catalytic cysteine abrogates enzymatic activity supporting the presence of two reaction centers per homodimer.

Continuous proliferation of cells in serum-free medium could be attributed to mutations of key genes (e.g., K-Ras).