As WHO criteria for Polycythaemia Vera diagnosis include the "presence of JAK2 V617F or similar mutation„ [5], detection of JAK2 exon 12 mutations is of importance for the 5 to 10% of patients presenting with a suspicion of PV but with no JAK2 V617F mutation.
Therefore, unlike in the first-line treatment of advanced GIST or in the adjuvant setting where mutation analysis is of importance, mutation analysis appears to have limited value in selection of systemic treatment for imatinib-resistant GIST.
One mutation of particular importance for clinical investigations is the multi-resistant substitution T315I, resulting in an amino acid change within the p-loop binding site.
Greater appreciation of the mechanisms responsible for regulating the PINK1 gene locus, beyond rare mutations, is of importance for a number of reasons.
When compared to the constant fitness case, cooperative lineage expansion with early mutator mutation limits the importance of mutator pathways when few oncogenic mutations are required for cancer (C = 2) and to some extent at C = 3 with a low wild type mutation rate (kmut), but for higher values of C, α50% continues to be well within commonly observed ranges.
The development and use of national mutation data is of importance to Omani medical care because it not only allows the genetic burden of disease to be quantified, but also provides diagnosticians and researchers access to an up-to-date resource that will assist them in their daily clinical practice and biomedical research.
The determination of the flower organ identity and the understanding of the development of the 'bud-flowering' mutation itself are of importance for future breeding efforts in C. vulgaris since the 'bud-flowering' phenotype is the most important breeding target in this species.
A cost effective approach to identifying mutations of critical importance for host range is to conduct comparative analyses of large groups of human and avian protein sequences, to identify candidate mutation sites that can subsequently be experimentally validated.
In addition to rare driver mutations of obvious importance, there are numerous passenger mutations found at low allelic frequency within the tumor population, presumably due to ongoing genetic stress within the tumor that results in tumor heterogeneity [ 5, 7, 12, 13].
The method besides its sensitivity, gives a complete view of the clonal distribution of mutations, which is of importance when making therapy decisions.
