Sentence examples for mutation of four from inspiring English sources

Mutation of four glycine residues within two proposed ATP binding motifs diminishes both geldanamycin binding and the ATP-dependent conversion of hsp90 to a conformation capable of binding the co-chaperone p23.

Full length human BChE with mutation of four glycosylation sites Asn17, Asn455, Asn481 and Asn486 was in expression vector pGS [10] and DNA of mouse BChE in pGS expression vector were a gift of Oksana Lockridge.

Similarly, mutation of four nonadjacent residues near the C-terminus to alanine caused complex maturation to be completely halted.

A similar decrease in sensitivity resulted from mutation of four positively charged P2X1 receptor residues in this region that are absent from the P2X2 receptor.

Constitutively active MAPK1 was generated by constructing a fusion between native ERK2 and MEK1, and subsequential mutation of four leucine residues in the export signal region to alanine, generating a hyperactivated MAPK1.

Site-specific sequential mutation of four GTGT motifs within this 106 bp region resulted in pronounced loss of silencing in homozygotes at both sites tested, identifying an essential role for this motif in silencing at the vg PRE.

Mutation of three cysteine residues (C4506, C4520 and C4537) abolished ABP labelling.

Andersen, J. T. et al. Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues.

Mutation of two putative phosphorylation sites in the N-terminus of KCNQ1 and one site in KCNE1 (S102) blocked the inhibition of Ang II.

Mutation of two of the sites, S324 and T515, partially inhibited the ability of muskelin to self-associate in cells and inhibited responsiveness to activated PKC.

Clayton, C. C., Donthamsetti, P., Lambert, N. A., Javitch, J. A. & Neve, K. A. Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor.