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Mutation of either lysine to alanine makes it less likely for a carbamate to form at the other site.
Germ-line mutation of either TSC gene leads to the development of the heritable disorder TSC.
Mutation of either one or both tyrosine residues to histidine conferred hydrolytic activity on previously inactive antibody 3F4.
Mutation of either serine 33 or serine 37 of p53 to alanine blocked the ability of GSK3β to regulate p53 transcriptional activity.
Furthermore, we demonstrate that the mutation of either T242 P or U7-U8 compensatesathetheffectcausedsed by the mutation of R7A on the replication of rVSVR7A.
Of the five individuals, four were found to have somatic EPAS1 mutations, all of which resulted in mutation of either amino acid residue A530 or P531 (P531R (x2), P531R, A530P 45.
No significant changes in the catalytic constants were observed upon mutation of either R82 or D207, and thus these residues appear to be nonessential for binding and/or catalytic activity.
The Huntington's disease mutation is genetically dominant and almost fully penetrant: mutation of either of a person's HTT genes causes the disease.
This effect was not significantly affected by mutation of either KEN box (data not shown).
In follicle cells, however, mutation of either gene produces defects in cell differentiation.
Similar(1)
Mutation of either of the two active site serines was found to block lipoamidase activity, while mutation of the active site lysine produced a partially active mutant.
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