Sentence examples for mutation of critical from inspiring English sources
First, dityrosine formation is induced by oxidative stress and second, is abrogated by tyrosine to phenylalanine mutation of critical residues.
Likewise, the deletion or mutation of critical domains flanking the ATPase, such as the bromodomain in SWI/SNF, has been shown to affect the function of the protein in many instances [42], [43], [44].
The ATPase activity of Snf2-like factors is essential for most of their biological functions, and point mutation of critical residues involved in ATP binding usually results in the same phenotype as the full deletion of the gene [39], [40], [41].
Mutation of critical residues in the putative signal sequence abolished its secretion.
Through mutation of critical amino acids or deletion of important functional domains, MECP2 mutations result in a loss of MeCP2 function.
CXXC4 interacts with Dvl-1 directly and the mutation of critical residues in the Dvl-interacting domain abrogated its interaction with Dvl-1.
Many genetic factors, such as mutations of critical genes (e.g. APC, MLH1, MSH2, TGFBR2 and SMAD4) have been identified [3].
A cost effective approach to identifying mutations of critical importance for host range is to conduct comparative analyses of large groups of human and avian protein sequences, to identify candidate mutation sites that can subsequently be experimentally validated.
Site 1, which is contiguous to the active site, is necessary for cleavage as mutations of critical residues in this site to either lysine or alanine abolish cleavage both by the isolated Josephin domain and by full-length ataxin-3.
Mutations of critical residues within hypothetical functional domains and in highly conserved sequences may be expected to have loss-of-function consequences.
Interestingly, 48 out of the reported 518 kinases in the human genome seem to have lost their kinase activity altogether due to mutations of critical amino acids in their kinase domains thought to be required for catalytic functions.
