Sentence examples for mutation of core from inspiring English sources

Site directed mutation of core binding nucleotides at NBE at 1.8 kb upstream to TSS further confirmed its role for enhancing the basal transcriptional activity of GDF9 promoter in buffalo oocytes.

Mutation of core Znf cysteine residues (C83A or C93A) destabilized the Stc1-FLAG protein (data not shown).

This raises the possibility that the underlying aetiology of disorders associated with the mutation of core cohesin components is different from that associated with the disruption of NIPBL.

In the present study, a RVA gene, TaRVA, was found to bind to the W-box motif "CTGACT", and the binding is lost following "G" to "A" or "A" to "G" mutation of core "TGAC" motif, suggesting a specific interaction.

The overlapping clinical features, including heart defects, distinctive facial appearances, skin and hair abnormalities, short stature and mental retardation, propelled the discovery that these syndromes are caused by germ-line mutations in the same genetic pathway, and reflect a common underlying molecular pathogenesis through mutation of core components of the Ras/MAPK signalling pathway.

We conclude that NIPBL has a function in modulating chromatin architecture, particularly for gene-rich areas of the chromosome, that is not dependent on SMC3/cohesin or CTCF, raising the possibility that the aetiology of disorders associated with the mutation of core cohesin components is distinct from that associated with the disruption of NIPBL itself in classical CdLS.

This case report describes clinical and radiographic manifestations at the age of 11 and 29 of a CCD patient, investigates the mutation of core-binding factor A1 (Cbased based on gene analysis, and illustrates successful oral reconstruction with fixed prosthesis and dental implant after the extraction of multiple teeth.

We carried out two types of mutations: (1) deletion of the region bearing the p53REs and (2) single mutations of core nucleotides in the p53REs within the cloned fragment (Scheme 2; Supplementary Table 4).

Moreover, the induction of germ cell death by DPE plus UVA was alleviated in single-gene loss-of-function mutations of core apoptotic, checkpoint HUS-1, CEP-1/p53, and MAPK dependent signaling pathways.

The HCV particle assembles in the vicinity of the LD in cultured hepatoma cells, and deletion or mutations of Core to disturb its LD targeting suppressed HCV production (Boulant et al. 2007; Miyanari et al. 2007).

Indeed, loss-of-function mutations of core APC/C subunits has been observed in colorectal cancer cells, upregulation of Cdc20 has been observed in several human cancers, and loss of Cdh1 causes chromosomal instability and tumour formation in mice (Wang et al, 2003; Nakayama and Nakayama, 2006; Garcia-Higuera et al, 2008).