Sentence examples for mutation of binding from inspiring English sources

Model simulations display the effects of mutation of binding sites, or perturbation of upstream gene expression.

As shown in Fig. 4E, the mutation of binding site 1, binding site 2, or both sites in the ADAM9 3′UTreverseded the miR-33a-induced downregulation of luciferase activity.

As is shown in Fig. 6D, the mutation of binding sites in 3′UTRs of NR2F2 reversed the downregulation on luciferase activity induced by miR-27b, and abrogated the suppressing effect of miR-27b overexpression.

As shown in Fig. 6B, a mutation of binding site 1 almost completely abolished the activity of miR-222, whereas a mutation of binding site 2 only slightly reduced miR-222 activity, indicating that the majority of miR-222 activity is due to the binding to the first consensus sequence.

The single point (D368A, D371A) and double point (D368A and D371A) mutations of the antigen showed a decrease (single point mutation) and loss (double point mutations) of binding affinity towards hexamminecobalt.

This allows the study of mutations of binding sites that do not knock components out but change their interactions [ 45].

All of these "active" constructs lost their FA growth-promoting activity when talin-binding was inhibited by mutation of its binding site in vinculin (A50I).

The mutation of individual binding sites showed no effect on PTB binding (data not shown, Fig 4a and b).

In previous paper, Nfic binds to Klf4 promoter but not to Klf4 promoter with the mutation of Nfic binding site [ 17].

CoCl2 increased the luciferase activities of the Vegf promoter region, and mutation of HIF1α binding sites blocked it (Supplementary Figure 1).

Using luciferase assay, the 3′-UTR of IKKβ was consolidated to be suppressed by miR-200b/c and mutation of the binding sites in the 3′-UTR of IKKβ impaired the responsiveness of IKKβ to miR-200b/c (Fig. 4a).