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Second, the compound cannot discriminate between CHCs that harbour mutation of any of the interaction sites on the NTD.
In their study, sequential mutational analysis revealed that FOXL2 binding was reduced by mutation of any of the 12 consecutive base pairs at their site.
Mutation of any of these tryptophans disrupts the architecture of the active site.
Thus, mutation of any single gene may cause a genomic imbalance, with consequences sufficient to drive adaptive genetic changes.
Mutation of any of its components results in loss of cell-cell adhesion, thereby contributing to malignancy.
Mutation of any of these five residues influences receptor binding; for example, mutations to E148, which abolished binding to VD1, impaired the interaction with VEGFR-2 but enhanced binding to VEGFR-3.
Mutation of any of the catalytic triad residues abolishes carboxylesterase activity (Alam et al., 2002b).
If so, mutation of any one of the three residues might well result in the loss of DNA binding activity.
Mutation of any two sites was shown to affect the receptor's surface expression (Norskov-Lauritsen and Brauner-Osborne, 2015; Norskov-Lauritsen et al., 2015).
Our data showed that mutation of any selected single base within M2 abolished the binding of GST-CTCF-ZFs to M2 (Fig. 2H).
Alanine mutation of any one of the eight zinc coordinating cysteine or histidine residues rendered the DraIII enzyme inactive at the cell lysate level (Table 2).
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