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Exact(10)
In other words, mutation of another gene does not happen.
It could also, however, be a mutation of another human coronavirus.
1) Does mutation of another GARP subunit show the same effect?
Mutation of another tRNA methyltransferases, NSUN2, has been associated with microcephaly, short stature, intellectual disability, and facial dysmorphism.
Further mutation of another lysine (K38; to generate 6KR) also did not impair the function of TRAF2 (data not shown).
A similar isosteric mutation of another Mg2+ coordinating residue, E116Q, reduced activity by 500-fold compared to wild type activity.
Similar(50)
Pathogenic mutations of another mitoribosomal protein gene, MRPS22 (NG_012174.1; GI:237874203), have also been reported in severe antenatal-onset infantile disease (Saada et al., 2007).
Recently, gain-of-function somatic mutations of another residue present in the JH2 domain (Arg683Gly/Ser/Lys) were found in 18% of patients suffering with Down's syndrome-associated acute lymphoblastic leukaemia [ 64 66].
Mutations of another autosomal dominant Parkinson's disease gene, LRRK2 (leucine-rich repeat kinase 2), has been shown to induce or inhibit autophagy depending on the cell type [ 200– 202].
On the contrary, mutation of LS5, another TGACG motif containing element, augmented PR1 expression (Kesarwani et al. 2007).
This is in sharp contrast with what is observed in mice with deletion of the entire APP intracellular domain or a point mutation of Tyr682, another conserved residues in the AID, which show early lethality similarly to APP−/−APLP2−/− animals [32], [33].
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