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Likewise, mutation occurrences of PaCa and OvCa drug targets are 2.05 and 9.99 times higher than those of putative non-drug targets.
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Next, we partitioned the 240 recurrently mutated genes into 5 'co-occurrence clusters' based on the correlation in their mutation occurrence patterns.
In conclusion, MGMT promoter methylation modulated by p53 status could partially promote p53 mutation occurrence in advanced lung tumors.
However, these parameters are poorly known, in large part because of the difficulty of designing and interpreting experiments to examine the rare and intrinsically stochastic process of mutation occurrence.
Position enrichment is measured using this normalized mutation occurrence.
The area of mutation occurrence is restricted mainly to Europe and parts of Asia.
We counted the number of all observed mutations in DNA sequence to decide mutation occurrence of each gene-product.
Similarly, a higher rate of DNA mutation occurrence due to oxidative damage is found in rats undergoing psychological distress [ 109].
These relevant features are gene essentiality score (GARP score), mRNA expression intensity (RMA score), DNA copy number, mutation occurrence and closeness centrality in the PPI network.
However, mechanisms of mutation occurrence may not be as straightforward as we have wished, and the results of in-depth analyses suggested a possibility of Lamarckian contributions [66 73].
Since each protein has a different size (coding sequence length) and different number of mutations, we normalized mutation occurrence (number of mutations in a gene) by coding sequence length for the fair comparison of the mutational property of proteins.
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