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This indicates that this mutation occurred very recently or there is still some kind of selection pressure for a functional enzyme.
The overall high sequence identity of the two chitinases between P. furiosus and T. kodakarensis indicates that this mutation occurred very recently or there is still some kind of selection pressure for a functional enzyme using programmed +/−1 frameshifting.
The overall high sequence identity of the two chitinases between P. furiosus and T. kodakarensis indicates that this mutation occurred very recently or there is still some kind of selection pressure for a functional enzyme using programmed +/−1 frameshifting [ 27].
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If a mutation occurs very early in embryonic development, it may appear in most cells in our body.
Our results demonstrated that in two patients, APOBEC-mediated mutations occurred very early in tumour development and could potentially be important in the initial neoplastic transformation (Fig. 2b).
Mutations occur very frequently and even mutations in oncogenes and tumour suppressor genes very rarely ever result in the initiation of a neoplastic growth and very few of these neoplastic lesions ever progresses to form a tumour of clinical significance.
The data also suggest that somatic POLE mutations occur very early during colorectal tumorigenesis, because the frameshift mutations found often at APC in unselected CRCs are not seen in tumors with EDMs.
The extreme example of this is the T72c2 cell line where, of the 30 plaques sequenced, 28 carried the same mutation, suggesting an event that occurred very early after transfection and selection.
Although this is not always the case, TET2 mutation frequently occurs before the JAK2 V617F mutation in the development of MPN [ 78, 85], suggesting that TET2 mutation may occur very early in cancer development.
Our data indicate that, relative to point mutations, this driver cytogenetic change occurred very early during the evolution of this particular tumor.
Therefore, there is evidence of inheritance of specific mutations throughout the viral evolution, with mutations that occur very early in infection being maintained during the generation of new variants.
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