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The pattern of linkage disequilibrium suggests that the HbE mutation occurred recently in Southeast Asia [ 6].
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The phylogenetic convergence or 'PhyC' approach [ 18] looked at recurrent mutations on the tips and internal nodes of the phylogenetic tree, assuming that mutations occurred recently under strong selection.
Pro appears to be a new mutation which possibly occurred recently in Bos indicus and was only observed in the Sahiwal sample.
If the mutation occurred relatively recently, it is possible the minor allele is gradually becoming more prevalent.
This indicates that this mutation occurred very recently or there is still some kind of selection pressure for a functional enzyme.
The overall high sequence identity of the two chitinases between P. furiosus and T. kodakarensis indicates that this mutation occurred very recently or there is still some kind of selection pressure for a functional enzyme using programmed +/−1 frameshifting [ 27].
The overall high sequence identity of the two chitinases between P. furiosus and T. kodakarensis indicates that this mutation occurred very recently or there is still some kind of selection pressure for a functional enzyme using programmed +/−1 frameshifting.
All of this newly identified variation is rare, with 72.0% being singletons, and 17.1% doubletons (Table 2, last column) and most of these mutations are likely to have occurred recently in the Danish population.
These alleles are typical of those found in C. jejuni from farm sources and are almost all identical to those found in the donor species, indicating that the imports occurred recently enough to have not accumulated mutations [25].
This has particularly important ramifications for species with low mutation rates such as elasmobranchs or in cases where isolation between populations has only occurred recently [ 26].
If the sweep occurred recently, there may not have been much time for compensatory mutations to neutralize this phenotypic effect [ 51].
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CEO of Professional Science Editing for Scientists @ prosciediting.com