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Exact(6)
We did not observe the mutation noted in the Spo0A gene by Rotta et al. [ 20].
The Gly514Glu mutation, noted in the second family, is also present in five cDNAs derived from cancer cell lines or tumors in the expressed sequence tag (EST) database.
In fact, the mutation noted in the current patient has been associated with the development of aHUS in the literature and is thought to alter the C-terminal domain of CFH [ 8].
Furthermore, the E547K mutation noted in two of our BRCAX patients has only once previously been reported in a single female breast cancer suggestive of a unique hot spot preferentially within male cancers.
In contrast, given the low proportion of isolates with injectable agent resistance and the lack of rrs or eis mutation noted in the isolates available for sequencing, as well as the absence of gyrA mutation in the isolates of borderline susceptibility to ofloxacin, new line-probe assays for these targets may be of less value [ 29].
Indeed, the similarities with FBC extend to the types and positions of mutations in MBC in PIK3CA with the frequencies of exon 20 mutations>exon 9 mutations>exon 5 mutations (aside from our previously reported E547K PIK3CA mutation (Deb et al, 2012a), which is rarely seen in FBC), and interestingly, the only gene mutation noted in more than one TCGA MBC sample was PIK3CA (two H1047R, one E545K).
Similar(54)
Mutations in chromatin state regulators are very common in ccRCC, with PBRM1/BAF180 mutations noted in 29%41%% of all ccRCCs (Hakimi et al., 2013a; Varela et al., 2011).
Overall, the V3 sequences were fairly constant over time, with only a few mutations noted in the later time point virus compared with the virus from the first visit (Figure 4).
The results of the current study demonstrated that the T790M mutation was not present in the blood before treatment with erlotinib in any of the 23 patients with sensitizing EGFR mutations noted in the pretreatment blood sample.
There have been multiple mutations noted in DLD genes in phosphine-resistant insects and nematodes, but the only mutation that has been identified in a phosphine-resistant population of T. castaneum was G131S [ 10].
On the basis of these experiments, we conclude that the presence of C8-dG-ABA in the bubble region of the duplex plasmid, in addition to the different sequence context and the type of cells, has contributed to the array of mutations noted in ref (60).
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