Sentence examples for mutation mouse strain from inspiring English sources

However, in a different study that investigated PS-1 KO mice, little effect on LTP was found, while a APP V717I) mutation mouse strain showed much impaired LTP.

In this study, Wt1R394W point mutation mice strain [ 34] was used to study the interaction of GR somatic cells and germ cells in gonad development.

67 A recessive loss-of-function mutation in EIF2AK4 mutant mouse strain was isolated by screening macrophage's susceptibility to virus infection.

This study identified and characterized a mutant mouse strain with a novel ENU-induced mutation in the Scarb1 gene (I179N).

Eight mouse strains with distinct mutations in Col4a1 and one mouse strain with a mutation in Col4a2 (25, 43) were backcrossed to C57BL/6J mice for a minimum of five generations to generate an allelic series of Col4a1 and Col4a2 mutant mice on a uniform genetic background (Supplementary Material, Table S1).

Fukada et al. previously bred the mdx mutation into the D2 mouse strain and compared the resulting strain to the historical mdx (C57BL/10) mouse [ 15].

To examine the background of the mouse strains, we performed a mutation analysis of Tlr4 exon 3. Tlr4 did not show a C to A transversion due to a missense mutation in the C3H/AnL mouse strain, which was reported to be present in the C3H/HeJ strain (Additional file 4: Figure S3) [ 23].

This meeting launched a trans-NIH initiative called the Knockout Mouse Project (KOMP) As of May 2012, the KOMP now contains approximately 8500 targeted null mutations in the C57BL/6 mouse strain (http://www.nih.gov/science/models/mouse/knockout/).

Autosomal recessive mutation derived diabetes in db/db mouse strain is spontaneously diabetic mice which was identified as a mutation in the leptin receptor gene [ 92].

It is therefore of particular interest that apoE−/− mice fed the same percentage cholesterol as the HC diet used in our study had reduced plaque development when the apoE−/− mutation was expressed in a mouse strain that completely lacks expression of arginase II [34].

For example, Npc1-null mutations put into the C57BL/6 mouse strain cause a more severe early defect (leading to premature death prior to obvious neurodegeneration) than in FVB/N, Balb/c or mixed genetic backgrounds.