Sentence examples for mutation model of from inspiring English sources

The original guidelines (published in 2000) have been revised, replacing a stratified pre- and full mutation model of fragile X syndrome with one based on a continuum of gene effects across the full spectrum of FMR1 CGG trinucleotide repeat expansion.

To test for a phylogeographic signal in the data, we also derived pairwise RST values, which accounts for the stepwise mutation model of microsatellite alleles [19], and compared these to RST values in which allele sizes were permuted (1000 times) among alleles (pRST) [20] using the software SPAGeDi version 1.3 [21.3

Generally, the data are consistent with the stepwise mutation model of microsatellite evolution.

Here we fit SEER data to parameterize a somatic mutation model of cancer.

The infinite site mutation model of sequence evolution was applied and loci were cut into non-recombining blocks.

However, ordinary HMMs and our earlier, simpler, point mutation model of simulated evolution require only sequence information, not structure.

The two-mutation model of Moolgavkar, Venzon, and Knudson corresponds to the case k = 2.

The models generalize the two-mutation model of Moolgavkar, Venzon, and Knudson, and also the Armitage-Doll model, and will be termed the generalized MVK model.

The two-mutation model of Moolgavkar, Venzon and Knudson (MVK) supposes that at age t there are X t) susceptible stem cells, each subject to mutation to an intermediate type of cell at a rate M 0)(t).

Subsequently, the stochastic two-mutation model of Moolgavkar and Venzon [ 2] generalized Knudson's model, by taking account of cell mortality at all stages as well as allowing for differential growth of intermediate cells.

A variety of quasi-mechanistic models of carcinogenesis are reviewed, all based on this somatic Darwinian evolutionary hypothesis; in particular, the multi-stage model of Armitage and Doll, the two-mutation model of Moolgavkar, Venzon, and Knudson (MVK), the generalized MVK model of Little and various further generalizations of these incorporating effects of genomic instability.