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Our simulation results are based on a certain pathway dynamics and mutation model; however, we believe that our findings generalize, which we can better understand on a genotype-phenotype space.
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In a finite population model, however, the number of mutations in the least-loaded class can increase over time owing to Muller's ratchet.
This was also shown in a mouse model, however in this model the mutation had a severe dominant negative effect (Pereira et al., 1997).
However, ordinary HMMs and our earlier, simpler, point mutation model of simulated evolution require only sequence information, not structure.
However, Global R-statistics based on the stepwise mutation model showed that significant population differentiation occurred at five loci, but not at the two others.
However, theory that underlies standard scans for selection assumes a simple mutation model.
However, because both mutation models gave qualitatively similar results, only the results with the single step mutation model are presented.
That model, however, is fundamentally unfair.
This model, however, is not self-consistent.
SMM: stepwise mutation model.
We call this mutation model 5 sites mutation.
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