Sentence examples for mutation might play from inspiring English sources

The identification of distinct heterozygous missense SDHB gene mutations in two T-ALL cell lines further suggests that the R46X mutation might play a functional role in the biology of PBMCs and leukemic T cells.

However, within palindromes, gene conversion, as well as stepwise mutation, might play a role in microsatellite dynamics and diversity.

Suspecting that rarer mutations might play a stronger role in schizophrenia, two teams of researchers looked for uncommon deletions or duplications of tiny DNA sequences within genes that occur only in individual patients or their close relatives.

Germline BMPR1A mutations predispose to juvenile polyposis syndrome; however, our findings indicate that also somatic mutations might play an important role in sporadic colorectal cancer development [29], [30], [31], [32], [33].

It was suggested that these mutations might play a role in the escape from immune-surveillance of these lymphomas [ 58, 59].

Although these results do not rule out the possibility that other earlier mutations might play an etiologic role in tumor formation, it is reasonable to expect that such mutations would trigger responses in DNA repair mechanisms if they were present.

Instead, environmental stress below the mutation threshold might play an essential role in the adaptation and evolution of life.

The fact that there were similar somatic mutations detected in our ACC cohort as reported in other tumor types raises the possibility that these mutations in particular might play a role in positively selecting for these cancer cells beyond random mutation.

Therefore, mutations in PSEN2 might play a role in Aβ, α-synuclein, and tau aggregation.

The implications of this unusual finding are of potential significance as regards the role somatic mutation and intraorganismal selection might play in genetic disease, not to mention the suitability of using blood-derived genomic DNA to evaluate patient mutational status of genetic diseases that affect various tissues.

However, recent studies have indicated that mutations of these genes might play distinct roles in tumor initiation and/or maintenance [10], [14].