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During this latter period, a somatic mutator mutation may occur (Figure 1C).
At some time during the acquisition of these initial D mutations, a somatic mutator mutation may occur.
Given that the 219 position is a part of the antigenic loop and that a single amino acid mutation in 219 increases human receptor-binding affinity, this mutation may occur as a part of antigenic drift in the currently circulating 2009 H1N1 strains.
During evolution, a mutation may occur at this locus.
This suggests that FGFR mutation may occur later during multifocal tumour development in some cases.
Allele association: The target mutation may occur on the ancestral or the new allele of a background interfering mutation; similarly, a future interfering mutation may occur on the ancestral or the new allele of the target mutation.
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Mutator mutations may occur in only a minority of premalignant lesions, but the mutator premalignant lesions are predicted to overwhelmingly be the ones that actually develop into cancers.
Suppressor mutations may occur within the gene carrying the primary mutation (intragenic suppressors) or in another gene, generating a phenotype that counterbalances the effect of the primary mutation.
Unlike inherited variants, cancer mutations may occur at low frequencies because of contamination from normal cells or tumor heterogeneity and can therefore be challenging to detect using common NGS analysis tools, which are often designed for constitutional genomic studies.
Therefore, mitochondrial disorders may be inherited in either a Mendelian (autosomal recessive, autosomal dominant, or X-linked) or maternal (mitochondrial) fashion, because mutations may occur in either the nuclear or mitochondrial genome.
Errors (mutations) may occur at each reproduction event, at each generation (a round of copies).
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